您根本不需要保存到临时目录。 只需将托管dll作为项目中的“嵌入式资源”即可。 然后挂钩Appdomain.AssemblyResolve事件，并在事件中，将资源作为字节流加载并从流中加载程序集并返回它。

示例代码：

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 // Windows Forms: // C#: The static contructor of the 'Program' class in Program.cs // VB.Net: 'MyApplication' class in ApplicationEvents.vb (Project Settings-->Application Tab-->View Application Events) // WPF: // The 'App' class in WPF applications (app.xaml.cs/vb) static Program() // Or MyApplication or App as mentioned above { AppDomain.CurrentDomain.AssemblyResolve += new ResolveEventHandler(CurrentDomain_AssemblyResolve); } static Assembly CurrentDomain_AssemblyResolve(object sender, ResolveEventArgs args) { if (args.Name.Contains("Mydll")) { // Looking for the Mydll.dll assembly, load it from our own embedded resource foreach (string res in Assembly.GetExecutingAssembly().GetManifestResourceNames()) { if(res.EndsWith("Mydll.dll")) { Stream s = Assembly.GetExecutingAssembly().GetManifestResourceStream(res); byte[] buff = new byte[s.Length]; s.Read(buff, 0, buff.Length); return Assembly.Load(buff); } } } return null; }